Table 1. Summary of genetic overlap using GRS and BUHMBOX.
Only the traits that have significant GRS p-values in positive directions are shown. Significant GRS p-value indicates evidence of shared genetic structure; significant BUHMBOX p-value indicates evidence of heterogeneity. See Supplementary Table 4 for the full results for all traits tested.
| Cohort data | Test trait | #SNP | GRS p-value | GRS Beta (95% CI) | BUHMBOX p-value | BUHMBOX power at π=0.20 |
|---|---|---|---|---|---|---|
| T1D | AA | 10 | 1.4 × 10−120 | 0.76 (0.69 – 0.82) | 0.83 | 0.15 |
| ATD | 7 | 1.4 × 10−31 | 0.48 (0.40 – 0.56) | 0.30 | 0.05 | |
| CEL | 38 | 2.2 × 10−35 | 0.32 (0.27 – 0.38) | 0.16 | 0.50 | |
| CRO | 119 | 2.4 × 10−05 | 0.08 (0.04 – 0.11) | 0.54 | 0.99 | |
| JIA | 22 | 3.6 × 10−151 | 0.44 (0.40 – 0.47) | 0.37 | 0.96 | |
| PBC | 19 | 1.1 × 10−12 | 0.16 (0.11 – 0.20) | 0.18 | 0.82 | |
| PSC | 12 | 4.1 × 10−26 | 0.38 (0.31 – 0.45) | 0.91 | 0.08 | |
| RA | 68 | 6.6 × 10−89 | 0.55 (0.49 – 0.60) | 0.45 | 0.40 | |
| SJO | 7 | 3.9 × 10−146 | 0.53 (0.49 – 0.57) | 0.84 | 0.66 | |
| SLE | 16 | 1.1 × 10−83 | 0.44 (0.39 – 0.48) | 0.79 | 0.91 | |
| VIT | 12 | 2.5 × 10−90 | 0.59 (0.53 – 0.65) | 0.14 | 0.33 | |
| RA | AA | 10 | 1.5 × 10−22 | 0.28 (0.22 – 0.34) | 0.71 | 0.23 |
| AS | 24 | 6.1 × 10−04 | 0.10 (0.04 – 0.15) | 0.19 | 0.20 | |
| ATD | 7 | 3.9 × 10−20 | 0.34 (0.27 – 0.41) | 0.57 | 0.08 | |
| CEL | 38 | 6.4 × 10−20 | 0.21 (0.17 – 0.26) | 0.57 | 0.63 | |
| JIA | 22 | 8.9 × 10−125 | 0.36 (0.33 – 0.39) | 0.61 | 0.99 | |
| PBC | 19 | 1.5 × 10−13 | 0.15 (0.11 – 0.19) | 0.83 | 0.90 | |
| PSC | 12 | 6.2 × 10−14 | 0.24 (0.18 – 0.31) | 0.46 | 0.12 | |
| SLE | 16 | 4.3 × 10−06 | 0.10 (0.05 – 0.14) | 0.34 | 0.96 | |
| SSC | 5 | 9.6 × 10−10 | 0.22 (0.15 – 0.29) | 0.08 | 0.09 | |
| T1D | 53 | 9.6 × 10−207 | 0.43 (0.40 – 0.46) | 0.29 | 1.00 | |
| VIT | 12 | 1.8 × 10−11 | 0.18 (0.12 – 0.23) | 0.02 | 0.41 | |
| Seroneg.RA | Seropos.RA | 14 | 1.1 × 10−10 | 0.30 (0.21 – 0.39) | 0.008 | 0.26 |
| MDD | SCZ | 90 | 1.5 × 10−5 | 0.17 (0.09 – 0.24) | 0.28 | 0.53 |
AA, Alopecia areata; AS, Ankylosing spondylitis; ATD, Autoimmune thyroid disease; CEL, celiac disease; CRO, Crohn’s disease; JIA, juvenile idiopathic arthritis; MS, multiple sclerosis; PBC, primary biliary cirrhosis; PSC, primary sclerosing cholangitis; SJO, Sjögren’s syndrome; SLE, systemic lupus erythematosus; SSC, Systemic sclerosis; UC, ulcerative colitis; VIT: Vitiligo; MDD, major depressive disorder; SCZ, schizophrenia; Seroneg., seronegative; Seropos., seropositive.