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Phase I Trials Published in Pediatric Oncology, 1990-2012. This flowchart illustrates the results of our literature search, which found 124 published phase I trials from 1990 to 2012, 97 of which were single-agent trials. 35 of these trials (bolded) had published phase II trials that met matching criteria and were ultimately included in analysis. The other trials were excluded from analysis for the reasons listed above. OR% = objective response rate.
