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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Trends Mol Med. 2016 Jun 3;22(7):615–628. doi: 10.1016/j.molmed.2016.05.005

Figure 4. Formation and Persistence of Stress Granules Potentially Cause RNP Hyper-Assembly Diseases.

Figure 4

Disease-causing mutations in RNA binding proteins, such as TDP-43, FUS and hnRNPA1/A2B1, can lead to formation of aberrant RNP granules, which share components of stress granules. Similarly, mutations that lead to increased persistence of stress granules, such as VCP or DNAJB6, can also lead to a variety of human diseases.