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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Trends Mol Med. 2016 Jun 3;22(7):615–628. doi: 10.1016/j.molmed.2016.05.005

Figure 5. Repeat Expansion in mRNAs as a Cause of RNP Hyper-Assembly Diseases.

Figure 5

A) CUG repeat expansion in the DMPK mRNA can sequester other RNA-binding proteins like MBNL in RNA foci, and inhibit alternative splicing of pre-mRNAs leading to disease pathology. B) G4C2 repeat expansion in the C9orf72 mRNA could sequester RNA binding proteins in nuclear foci, or can be translated into dipeptide repeats that can also aggregate with other RNA-protein complexes in the cytoplasm. These cytoplasmic aggregates could possibly inhibit nucleo-cytoplasmic transport of cellular components.