Table 2.
Excipients co-encapsulated with IPV in PLGA microspheres. Percentages refer to the mass ratio of excipients to the PLGA microspheres.
| Formulation | Number-weighted mean diameter (μm) | Sugars/sugar alcohols | Amino acids | Proteins | Divalent salt | Other |
|---|---|---|---|---|---|---|
| F1 | 5.8 ± 3.6 | – | – | 8% gelatin | – | – |
| F2 | 10.7 ± 3.4 | 8% sucrose | 6.8% MSG | – | 6.8% MgCl2 | – |
| F3 | 10.2 ± 3.3 | 8% maltodextrin | 6.8% MSG | – | 6.8% MgCl2 | – |
| F4 | 10.3 ± 3.4 | 8% sucrose | 6.8% MSG | – | 6.8% MgCl2 | 5% Mg(OH)2 |
| F5 | 8.7 ± 3.5 | 8% sucrose | 6.8% MSG | – | 6.8% MgCl2 | 0.4% l-arginine |
| F6 | 8.3 ± 3.5 | 8% maltodextrin | 6.8% MSG | – | 6.8% MgCl2 | 7.5% EPO |
| F7 | 7.7 ± 3.4 | 8% maltodextrin | 6.8% MSG | – | 6.8% MgCl2 | 5% EPO |
| F8 | 11.2 ± 3.4 | 8% maltodextrin | 6.8% MSG | – | 6.8% MgCl2 | 3% EPO |
| F9 | 10.5 ± 3.3 | 8% maltodextrin | 6.8% MSG | – | 6.8% MgCl2 | 5% EPO, 0.4% arginine |