Table 1.
Diagnostic criteria of CNL according to WHO 2008 classification and comparision with present case
| No. | Criterias | WHO diagnostic criteria | Our patient | |
|---|---|---|---|---|
| Values | Criteria fulfilled | |||
| 1. | Peripheral blood leukocytosis With segmented neutrophils | >25 109/l > 80 % | 45,700 83 % mature neutrophils | ✓ |
| 2. | Bone marrow biopsy | Hyper cellular with mature forms | 90–100 % cellular with mature forms | ✓ |
| 3. | Hepatosplenomegaly | To be present | 1. Hepatomegaly (3 cm below RCM) 2. Splenomegaly (12 cm below LCM) | ✓ |
| 4. | Physiologic neutrophilia | To be ruled out | Was not found | ✓ |
| 5. | BCR/ABL fusion gene | Must be absent | RQPCR for BCR-ABL (negative) | ✓ |
| 6. | PDGFRA, PDGFRB, or FGFR1 rearrangement | Must be absent | Negative | ✓ |
| 7. | Other myeloproliferative disease (PV,ET,PMF) | To be ruled out | JAK2V617F (negative) | ✓ |
| 8. | MDS or MDS/MPN syndrome | To be ruled out | No dysplasia noted | ✓ |