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. 2016 Jun 8;12:47–56. doi: 10.1016/j.nicl.2016.06.006

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Effects of marijuana use on subcortical shape in the restricted sample of unrelated users and the group comparison of users and non-users. (A) Trend for a significant negative relationship between number of times used and scalar values in the left amygdala. Participants with a higher number of times used showed more inward deflection in the superficial group of the left amygdala. FWE-corrected p < 0.09. (B) Significant negative relationship between age of first use and scalar values in the left nucleus accumbens. Participants with a earlier age of first use showed more inward deflection in the right posterior ventral accumbens. FWE-corrected p < 0.05. (C) Significant negative association between times used marijuana and scalar values in the left hippocampus. Participants with greater number of lifetime uses showed more inward deflection in the anterior hippocampus cornu ammonius. FWE-corrected p < 0.05. (D) Significant group effect between users and non-users on shape in the right amygdala. Users showed greater outward deflection of the superficial group of the amygdala (left image) and the laterobasal amygdala (right image) compared to non-users. FWE-corrected p < 0.05. (E) Significant group effect between users and non-users on shape in the left hippocampus (view of the medial surface, with right posterior hemisphere cropped). Users showed greater outward deflection of the hippocampus subiculum relative to non-users. FWE-corrected p < 0.05.