Central Illustration.

The Role of Fat Deposition in Type 2 Diabetes: Examples of ¹H-MRS, and Transaxial Liver ShMOLLI T₁ Map in a Healthy Volunteer, a Lean Patient With T2D, and an Obese Patient With T2D

(A) Proton magnetic resonance spectroscopy (¹H-MRS) of healthy volunteer with hepatic triglyceride (TG) 2.5%. (B)¹H-MRS of lean patient with type 2 diabetes (T2D) with hepatic TG 7.6%. (C) Obese patient with T2D with hepatic TG 16.1%. (D) Healthy volunteer with liver Shortened Modified Look-Locker Inversion recovery (ShMOLLI) T₁ map with corrected T₁ (cT₁) 748 ms. (E) Lean patient with T2D with liver ShMOLLI T₁ map with cT₁ 772 MS. (F) Obese patient with T2D with liver ShMOLLI T₁ map with cT₁ 1244 ms. BMI = body mass index.