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. 2016 Jun 29;7:191. doi: 10.3389/fphar.2016.00191

Figure 5.

Figure 5

Anti-metastatic effect of icariin and its derivatives. Icariin, icaritin, and icariside II inhibit metastasis of tumor by inhibiting cell adhesion, migration, and invasion through multiple mechanisms that resulted in downregulation of VASP, CXCR4, uPAR, ADM, and matrix metalloproteinases.