Table 3.
Compound | Model/Cell Line | Study Type | Observation/Mechanism | References |
---|---|---|---|---|
Herba Epimedii ethyl acetate fraction | HUVECS and Zebrafish embryos | In vitro and In vivo | Inhibition of HUVECs proliferation, migration, and VEGF-induced tube formation as well as significant inhibition of blood vessel formation in zebrafish embryos, due to inhibition of ERK signaling pathways | Yu et al., 2013 |
Icariin | HepG2 tumor | In vivo | Decrease in CD31+ vessels in tumor | Yang et al., 2009 |
HUVECS and CAM Assay | In vitro and In vivo | Inhibition of proliferation of HUVECs and inhibition of angiogenesis in CAM, reduced expression of VEGF | Ye et al., 2015 | |
Icaritin | CAM Assay | In vivo | Inhibition of angiogenesis in CAM | Hong et al., 2013 |
Renca tumor | In vivo | Decrease in the mean positive area of CD31 in immunohistochemical analyses of tumor, reduced expression of VEGF, due to inhibition of activity of STAT3 | Li et al., 2013b | |
HUVECS | In vitro | Inhibition of HUVEC proliferation, migration and tube formation | Zhang, 2014 | |
Icariside II | HUVECS | In vitro | Inhibition of angiogenic function with reduced widths and lengths of the endothelial network-like structures in HUVECS, reduced expression of VEGF in human osteosarcoma cells | Choi et al., 2008 |