Icariin |
Human lung adenocarcinoma cells (A459) |
In vitro |
Decreased migration and adhesion of cells |
Di et al., 2015
|
|
Human lung cancer cells (PG) |
In vitro |
Decreased cell adhesive ratio to laminin substrate and reduced cell ability of invasion or migration |
Mao et al., 2000
|
|
Gastric carcinoma cells (BGC-823) |
In vitro |
Inhibition of cells migration through downregulation of cell motility-related genes Rac1 and VASP |
Wang et al., 2010
|
Icaritin |
Human glioblastoma cells (U87MG) |
In vitro |
Downregulation of EMMPRIN via the PTEN/Akt/HIF-1α signaling pathway |
Xu et al., 2015
|
|
Human osteosarcoma cells (SaOS2) |
In vitro |
Decreased cell motility, through downregulation of MMP-2 and MMP-9 expression |
Wang and Wang, 2014
|
Icariside II |
Human osteosarcoma cells (HOS) |
In vitro |
Inhibition of the transcription of hypoxia-inducible genes involved in invasion/migration, such as uPAR, ADM, and MMP2 |
Choi et al., 2008
|
|
Human cervical cancer cells (HeLa) and Breast cancer cells (MDA-MB-231) |
In vitro |
Downregulation of the expression of CXCR4, through suppression of NF-κB activation |
Kim and Park, 2014
|
|
Human non-small cell lung cancer cells (A549 and H1299) |
In vitro and In vivo
|
Inhibit of TNF-α-induced migration and EMT of cancer cells in vitro and in vivo, through inhibition of Akt/NF-κB pathway |
Song et al., 2016
|