Table 5.
Applications of icariin and its derivatives with current cancer therapy.
| Compound | Cell Line | Study Type | Drug/Treatment | Effect | References |
|---|---|---|---|---|---|
| Icariin | Human Hepatocellular Carcinoma (SMMC-7721 and HepG2) | In vitro and In vivo | Arsenic trioxide | Potentiates antitumor effect of arsenic trioxide through by generation of intracellular ROS and inhibition of NF-κB activity | Li et al., 2014a |
| Human colorectal carcinoma cells (HT29 and HCT116) | In vitro and In vivo | 5-fluorouracil | Potentiates antitumor effect of 5-fluorouracil through inhibition of NF-κB activity | Shi et al., 2014 | |
| Human myeloid leukemia cells (HL-60 and NB4) | In vitro | Arsenic trioxide | Potentiates antitumor effect of arsenic trioxide through generation of intracellular ROS | Wang et al., 2015c | |
| Human glioblastoma cells (U87MG) | In vitro | Temolozomide | Potentiates antitumor effect of temolozomide through inhibition of NF-κB activity | Yang et al., 2015 | |
| Human gallbladder carcinoma cells (GBC-SD and SGC-996) | In vitro and In vivo | Gemcitabine | Potentiates antitumor effect of gemcitabine through inhibition of NF-κB activity and downregulation of NF-κB -regulated gene products | Zhang et al., 2013 | |
| Colorectal Cancer Cells (HCT116 and HT29) | In vitro and In vivo | X-ray irradiation | Potentiate radiation-induced apoptosis of cancer cells through suppression of radiation-induced NF-κB activation and downregulation of NF-κB -regulated gene products | Zhang et al., 2014 | |
| Icaritin | Murine breast cancer cells (4T1) | In vitro | Ionizing radiation | Potentiate radiation-induced apoptosis and inhibition of cell proliferation as well as suppression of IR-induced survival path, ERK1/2 and AKT | Hong et al., 2013 |
| Bladder cancer cells (BT5637 and T24) | In vitro | Epirubicin | Inhibition of epirubicin-induced autophagy and synergistic effect with epirubicin to suppress cancer cell proliferation | Pan et al., 2016 | |
| Extranodal NK/T-cell lymphoma cells (SNK-10 and SNT-8) | In vitro | Ganciclovir | Potentiates ganciclovir-induced apoptosis through induction of lytic EBV infection | Wu et al., 2015b | |
| Icariside II | Multiple myeloma cells (U266) | In vitro | Bortezomib and Thalidomide | Enhanced cytotoxicity of bortezomib and thalidomide through enhancement of apoptosis | Kim et al., 2011 |
| Human melanoma cells (A375) | In vitro | Paclitaxel | Potentiates paclitaxel-induced apoptosis through inhibition of paclitaxel activated TLR4–MyD88–ERK signaling | Wu et al., 2012 |