Icariin |
Human Hepatocellular Carcinoma (SMMC-7721 and HepG2) |
In vitro and In vivo
|
Arsenic trioxide |
Potentiates antitumor effect of arsenic trioxide through by generation of intracellular ROS and inhibition of NF-κB activity |
Li et al., 2014a
|
|
Human colorectal carcinoma cells (HT29 and HCT116) |
In vitro and In vivo
|
5-fluorouracil |
Potentiates antitumor effect of 5-fluorouracil through inhibition of NF-κB activity |
Shi et al., 2014
|
|
Human myeloid leukemia cells (HL-60 and NB4) |
In vitro |
Arsenic trioxide |
Potentiates antitumor effect of arsenic trioxide through generation of intracellular ROS |
Wang et al., 2015c
|
|
Human glioblastoma cells (U87MG) |
In vitro |
Temolozomide |
Potentiates antitumor effect of temolozomide through inhibition of NF-κB activity |
Yang et al., 2015
|
|
Human gallbladder carcinoma cells (GBC-SD and SGC-996) |
In vitro and In vivo
|
Gemcitabine |
Potentiates antitumor effect of gemcitabine through inhibition of NF-κB activity and downregulation of NF-κB -regulated gene products |
Zhang et al., 2013
|
|
Colorectal Cancer Cells (HCT116 and HT29) |
In vitro and In vivo
|
X-ray irradiation |
Potentiate radiation-induced apoptosis of cancer cells through suppression of radiation-induced NF-κB activation and downregulation of NF-κB -regulated gene products |
Zhang et al., 2014
|
Icaritin |
Murine breast cancer cells (4T1) |
In vitro |
Ionizing radiation |
Potentiate radiation-induced apoptosis and inhibition of cell proliferation as well as suppression of IR-induced survival path, ERK1/2 and AKT |
Hong et al., 2013
|
|
Bladder cancer cells (BT5637 and T24) |
In vitro |
Epirubicin |
Inhibition of epirubicin-induced autophagy and synergistic effect with epirubicin to suppress cancer cell proliferation |
Pan et al., 2016
|
|
Extranodal NK/T-cell lymphoma cells (SNK-10 and SNT-8) |
In vitro |
Ganciclovir |
Potentiates ganciclovir-induced apoptosis through induction of lytic EBV infection |
Wu et al., 2015b
|
Icariside II |
Multiple myeloma cells (U266) |
In vitro |
Bortezomib and Thalidomide |
Enhanced cytotoxicity of bortezomib and thalidomide through enhancement of apoptosis |
Kim et al., 2011
|
|
Human melanoma cells (A375) |
In vitro |
Paclitaxel |
Potentiates paclitaxel-induced apoptosis through inhibition of paclitaxel activated TLR4–MyD88–ERK signaling |
Wu et al., 2012
|