Table 3.

Mutants with reduced locomotion.

Mutant	Responsible gene	Alleles	Substitutions	Cause of defective behavior	References
sofa potato sop	Acetylcholine receptor δ subunit gene on chromosome 24	tj19d ts29 tf207c	L28P Unknown Unknown	Loss of neuromuscular transmission due to defect in acetylcholine receptor clustering	Granato et al., 1996; Ono et al., 2001, 2004
relaxed red	Dihydropyridine receptor β1a subunit gene (CACNB1) on chromosome 3	ts25 mi90	W451X Y283X	Defect in excitation-contraction coupling	Granato et al., 1996; Zhou et al., 2006; Schredelseker et al., 2009
nicotinic receptor nic	Acetylcholine receptor α subunit gene on chromosome 6	tk48d	Unknown	Loss of neuromuscular transmission due to defect in acetylcholine receptor clustering	Granato et al., 1996
heart attack hat	Unknown	te313	Unknown	Unknown	Granato et al., 1996
herzschlag hel	Titin gene (ttna) on chromosome 9	tg287	Unknown	Unknown	Granato et al., 1996; Myhre et al., 2014
unplugged unp	Muscle specific receptor tyrosine kinase gene on chromosome 10	te314b	Unknown	Defect in initial outgrowth of motor axons	Granato et al., 1996; Lefebvre et al., 2007; Jing et al., 2009
shocked sho	Glycine transporter 1 gene (slc6a9) on chromosome 2	ta51e te301 ta229g	Unknown C893Y G81D	Over-activation of glycinergic synapse by elevated extracellular glycine level	Granato et al., 1996; Luna et al., 2004; Cui et al., 2005; Mongeon et al., 2008
twitch once two	Acetylcholine receptor clustering factor rapsyn gene (rapsn) on chromosome 18	th26e tm335 tq265b	G130E Unknown Unknown	Loss of neuromuscular transmission due to defect in acetylcholine receptor clustering	Granato et al., 1996; Ono et al., 2002, 2004
alligator ali	RING finger protein 121 gene (rnf121) on chromosome 21	tm342 mi500	L39X V232A	Defect in the excitability of sensory Rohon-Beard neurons	Granato et al., 1996; Ogino et al., 2015
fakir far	α subunit of voltage-gated calcium channel 2.1b gene (CACNA1Ab)on chromosome 11	tm154	L356V	Reduced synaptic transmission between Rohon-Beard neuron and interneuron	Granato et al., 1996; Low et al., 2012
macho mao	Pigk gene (pigk) on chromosome 2	tt261	M1T	Defect in the excitability of sensory Rohon-Beard neurons	Granato et al., 1996; Carmean et al., 2015
steifftier ste	Unknown	tf220	Unknown	Defect in the excitability of sensory Rohon-Beard neurons	Granato et al., 1996
crocodile cro	Unknown	tw212d m148 s3556	Unknown Unknown Unknown	Unknown	Granato et al., 1996
schlaffi sla	Unknown	ty112 th239 tg230	Unknown Unknown Unknown	Unknown	Granato et al., 1996
slumber slm	Unknown	tt208 tm221 tm132c	Unknown Unknown Unknown	Unknown	Granato et al., 1996