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. 2016 May 7;3:63–72. doi: 10.1016/j.dadm.2016.04.001

Fig. 2.

Fig. 2

Human plasma NDE levels of P-T181-tau, P-S396-tau, Aβ1–42, NRGN, and REST delineate stages of AD. (A) Plasma NDE levels of CD81 were not statistically different among the four clinical cohorts as measured by ELISA. Significantly different levels of (B) Aβ1–42, (C) P-T181-tau, (D) P-S396-tau, (E) NRGN, and (F) REST were detected by ELISAs in the plasmas of CNC (n = 10), stable MCI (n = 20), ADC (n = 20), and AD (n = 10) patients. Plasma NDE levels of P-T181-tau, P-S396-tau, and Aβ1–42 were significantly higher, whereas those of NRGN and REST were significantly lower for ADC and AD patients than CNC subjects and stable MCI patients. The horizontal line in each cluster depicts the mean for that set. * = P < .05, ** = P < .01, *** = P < .0001 versus CNC; ## = P < .01, ### = P < .0001 versus MCI. Abbreviations: NDE, neuronal derived exosome; CNC, cognitively normal controls; MCI, mild cognitive impairment; ADC, MCI converting to AD.