Table 2. Parameters measured in the Elevated Plus Maze Test (EPM). (n): number of events.

	Wt 2 months	5XFAD2 months	Wt 8 months	5XFAD8 months
Locomotor activity (cm)	1,161.79 ± 89.91	1,360.81 ± 94.74	1,087.42 ± 135.49	764.18 ± 157.50##
Time in zone-Center (sec)	34.35 ± 5.67	42.13 ± 3.45	28.93 ± 6.42	19.22 ± 4.86#
Time in zone- Open Arms (sec)	67.16 ± 7.93	59.28 ± 12.85	40.17 ± 8.96	118.25 ± 37.15$
Time in zone- Closed Arms (sec)	198.11 ± 10.03	198.06 ± 14.87	230.15 ± 13.43	162.23 ± 35.18
Rearings (n)	13.33 ± 1.02	17.58 ± 1.05	15.88 ± 2.15	7.57 ± 1.86####,$$
Defecations (n)	0.67 ± 0.27	0.83 ± 0.33	0.75 ± 0.49	0.29 ± 0.29
Urinations (n)	0.22 ± 0.17	0.17 ± 0.14	0.25 ± 0.16	0.14 ± 0.14

Results are expressed as a mean ± Standard error of the mean (SEM).

^*p <0.05

^**p <0.05

^***p<0.001 vs Wt, 2 months

^#p <0.05

^##p <0.001 vs 5XFAD, 2 months

^$p<0.05 vs Wt, 8 months.