Table 3. Parameters measured in the Open Field Test (OFT).
| Wt 2 months | 5XFAD2 months | Wt 8 months | 5XFAD8 months | |
|---|---|---|---|---|
| Total Distance (cm) | 2,296.28 ± 235.08 | 2,686.37 ± 260.57 | 2,083 ± 246.02 | 1,383.31 ± 291.40*,##,$ |
| Distance in Zone Center (cm) | 46.64 ± 10.01 | 40.62 ± 8.06** | 266.05 ± 48.34**** | 166.72 ± 44.46****,## |
| Distance in Zone Periphery | 2,249.65 ± 228.66 | 2,645.76 ± 258.96* | 1,817.83 ± 221.38*** | 1,218.98 ± 255.46****,## |
| Center (%) | 16.91 ± 1.82 | 11.60 ± 1.63 | 7.00 ± 1.55** | 4.81 ± 1.26***,# |
| Periphery (%) | 83.09 ± 0.80 | 88.40 ± 1.63* | 93.00 ± 1.55**** | 95.19 ± 1.26****,## |
| Rearings (n) | 25.89 ± 3.45 | 29.08 ± 3.20 | 17.29 ± 2.04 | 7.29 ± 2.68**,### |
| Defecations (n) | 0.44 ± 0.19 | 0.33 ± 0.25 | 1.14 ± 0.51 | 0.57 ± 0.20 |
| Urinations (n) | 0.33 ± 0.18 | 0.08 ± 0.11 | 0.00 ± 0.00 | 0.00 ± 0.00 |
(n): number of events. Results are expressed as a mean ± Standard error of the mean (SEM)
*
p <0.05
**
p <0.05
***
p<0.001 vs Wt, 2 months
#
p <0.05
##
p <0.001 vs 5XFAD, 2 months
$
p<0.05 vs Wt, 8 months.