Figure 1. Average trajectories of grip strength, maximum running distance, and body weight over time by intervention status and sex.

The dashed and solid lines respectively represent rapamycin-treated and placebo group-specific mean trajectories estimated from the linear random effects model that took into account the premature deaths; the triangles and solid cycles respectively represent rapamycin-treated and placebo group-specific cross-sectional means based solely on the survivors at the time of each evaluation.