Table 2. Randomized, placebo-controlled study of enteric rapamycin-treatment in old LCR Rats: Study variables and data collection timeline.
| Timeline (Week) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 2 | 4 | 6 | 8 | 10 | 12 | 14 | 16 | 18 | 20 | 22 | 24 | 26 | 28 | 30 | 32 | |
| Rapamycin feeding |  |
||||||||||||||||
| Study Measure | |||||||||||||||||
| Grip Strength | ♂/♀ | ♀ | ♀ | ♂/♀ | ♀ | ♀ | ♂/♀ | ♀ | ♂/♀ | ||||||||
| MRD | ♂/♀ | ♀ | ♂ | ♀ | ♂/♀ | ♂ | ♀ | ||||||||||
| Body Weight | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ | ♂/♀ |
| Blood Rapamycin Levels | ♂* | ♀# | ♂* | ♀# | |||||||||||||
| Food Intake | ♂/♀ | ♂ | ♀ | ♂ | ♂/♀ | ♀ | |||||||||||
| Fasting Glucose | ♀ | ♀ | ♀ | ♀ | ♀ | ♀ | ♀ | ♀ | ♀ | ♀ | ♂/♀ | ♀ | |||||
MRD: Maximum running distance
*
Measured in a random sample of 3 rapamycin-treated male rats at 4 weeks and 4 rapamycin-treated male rats at 16 weeks.
#
Measured in all 8 rapamycin-treated female rats at 10 weeks and 7 rapamycin-treated female rats at 18 weeks.