Table 3.
Gene targets of candidate microRNAs from PI3K/Akt signaling, hippo signaling and focal adhesion pathways (enriched P < 0.001, extracted from starBase: http://starbase.sysu.edu.cn).
| PI3K-Akt signaling pathway | |||
|---|---|---|---|
| Gene targets | RefSeq/Gene name | microRNA | Position |
| COL1A1 | NM_000088//collagen, type I, alpha 1 | hsa-let-7i-5p | chr17:48262068-48262074[−] |
| ITGB8 | NM_002214//integrin, beta 8 | hsa-miR-106b-5p | chr7:20449851-20449858[+] |
| RBL2 | NM_005611//retinoblastoma-like 2 | hsa-miR-106b-5p | chr16:53524846-53524853[+] |
| CCND2 | NM_001759//cyclin D2 | hsa-miR-17-5p | chr12:4410143-4410149[+] |
| CDKN1A | NM_000389//cyclin-dependent kinase inhibitor 1A (p21, Cip1) | hsa-miR-17-5p | chr6:36654725-36654731[+] |
| JAK1 | NM_002227//Janus kinase 1 | hsa-miR-17-5p | chr1:65298950-65298956[−] |
| EFNA3 | NM_004952//ephrin-A3 | hsa-miR-210-3p | chr1:155059817-155059823[+] |
| YWHAG | NM_012479//tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma | hsa-miR-222-3p | chr7:75956151-75956157[−] |
| ITGA5 | NM_002205//integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | hsa-miR-25-3p | chr12:54789081-54789088[−] |
| CSF1 | NM_000757//colony stimulating factor 1 (macrophage) | hsa-miR-27a-3p | chr1:110472264-110472271[+] |
| KITLG | NM_000899//KIT ligand | hsa-miR-27a-3p | chr12:88890807-88890814[−] |
| AKT3 | NM_001206729//v-akt murine thymoma viral oncogene homolog 3 | hsa-miR-93-5p | chr1:243667403-243667409[−] |
| Hippo signaling pathway | |||
| GDF6 | NM_001001557//growth differentiation factor 6 | hsa-let-7i-5p | chr8:97154690-97154697[−] |
| TGFBR1 | NM_001130916//transforming growth factor, beta receptor 1 | hsa-let-7i-5p | chr9:101911662-101911669[+] |
| CCND2 | NM_001759//cyclin D2 | hsa-miR-17-5p | chr12:4410143-4410149[+] |
| FRMD6 | NM_001042481//FERM domain containing 6 | hsa-miR-20a-5p | chr14:52194908-52194915[+] |
| TGFBR2 | NM_001024847//transforming growth factor, beta receptor II (70/80 kDa) | hsa-miR-21-5p | chr3:30733297-30733303[+] |
| YWHAG | NM_012479//tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma | hsa-miR-222-3p | chr7:75956151-75956157[−] |
| PPP1CB | NM_002709//protein phosphatase 1, catalytic subunit, beta isozyme | hsa-miR-23a-3p | chr2:29022976-29022982[+] |
| PPP1CC | NM_002710//protein phosphatase 1, catalytic subunit, gamma isozyme | hsa-miR-27a-3p | chr12:111158440-111158447[−] |
| Focal adhesion | |||
| COL1A1 | NM_000088//collagen, type I, alpha 1 | hsa-let-7i-5p | chr17:48262068-48262074[−] |
| ITGB8 | NM_002214//integrin, beta 8 | hsa-miR-106b-5p | chr7:20449851-20449858[+] |
| MAPK9 | NM_002752//mitogen-activated protein kinase 9 | hsa-miR-106b-5p | chr5:179663017-179663023[−] |
| CCND2 | NM_001759//cyclin D2 | hsa-miR-17-5p | chr12:4410143-4410149[+] |
| PPP1CB | NM_002709//protein phosphatase 1, catalytic subunit, beta isozyme | hsa-miR-23a-3p | chr2:29022976-29022982[+] |
| ITGA5 | NM_002205//integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | hsa-miR-25-3p | chr12:54789081-54789088[−] |
| PPP1CC | NM_002710//protein phosphatase 1, catalytic subunit, gamma isozyme | hsa-miR-27a-3p | chr12:111158440-111158447[−] |
| VCL | NM_003373//vinculin | hsa-miR-34a-5p | chr10:75878809-75878815[+] |
| AKT3 | NM_001206729//v-akt murine thymoma viral oncogene homolog 3 | hsa-miR-93-5p | chr1:243667403-243667409[−] |