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Hematoxylin and eosin (H&E) staining showed reactive changes including vacuolization suggestive of edema and astrocytosis/gliosis (A). Glial fibrillary acidic protein (GFAP) staining highlighted reactive astrocytes (B). H&E staining also demonstrated thickened blood vessels with perivascular hemosiderin deposition (C), and beta-amyloid immunohistochemistry revealed beta-amyloid deposition in blood vessel walls (D). These findings were consistent with cerebral amyloid angiopathy.
