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. 2016 Jun 15;2016:1421430. doi: 10.1155/2016/1421430

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Copyright © 2016 Bin Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Concentration-dependent cytotoxicity of cultured hippocampal neurons induced by exposure under different Aβ concentrations from 20 to 400 μM. Metformin alleviated Aβ-induced cytotoxicity also in a dose-dependent manner. (a) and (b) Quantitative analysis of MTT and LDH release assay showed that Aβ decreased cell viability from 50 to 200 μM (^∗ p < 0.05, ^∗∗ p < 0.01 versus that of control, n = 6 per group). (c) and (d) Quantitative analysis of MTT and LDH release assay represented that metformin pretreatment decreased injuries induced by 200 μM Aβ in a concentration-dependent way. As shown in (c) and (d), 100 mM metformin can increase the neuronal viability distinctively.