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. 2016 Jun 15;2016:1421430. doi: 10.1155/2016/1421430

Figure 3.

Figure 3

Metformin salvaged Aβ-induced cytotoxicity via MAPK JNK signaling pathway. (a) and (b) Quantitative analysis of MTT and LDH represented that Aβ increased the phosphorylation of JNK, which could be reserved by metformin treatment ( p < 0.05, n = 5). In addition, anisomycin treatment blocked metformin-involved protection, suggesting the depression of JNK had a vital role in the effect of metformin.