Table 2.
Univariate analyses (Cox regression model) of OS and DFS in relation to various prognostic parameters and TROP2's expression
| Variables | OS P‐value | HR | 95% CI | DFS P‐value | HR | 95% CI |
|---|---|---|---|---|---|---|
|
TROP2 IHC Low/overexpression |
0.00 | 2.84 | 1.65–4.88 | 0.00 | 3.00 | 1.74–5.17 |
|
Age <50/≥50 |
0.16 | 0.70 | 0.42–1.15 | 0.14 | 0.69 | 0.42–1.14 |
|
Histological type Non‐serous/serous |
0.00 | 2.13 | 1.28–3.53 | 0.00 | 2.23 | 1.34–3.70 |
|
FIGO stage <IIIC/≥IIIC |
0.00 | 5.46 | 2.67–11.16 | 0.00 | 5.29 | 2.60–10.78 |
|
Histological grade G1/G2 |
0.23 | 1.76 | 0.70–4.39 | 0.19 | 1.84 | 0.74–4.59 |
|
Omental metastases No/yes |
0.00 | 2.60 | 1.55–4.36 | 0.00 | 2.54 | 1.52–4.24 |
|
Lymph node involvement No/yes |
0.00 | 2.52 | 1.52–4.18 | 0.00 | 2.57 | 1.55–4.26 |
|
Presence of ascites No/yes |
0.83 | 1.06 | 0.64–1.75 | 0.66 | 1.12 | 0.68–1.85 |
TROP2 IHC Low expression: total score 0–4; TROP2 IHC Overexpression: total score 6–12.
OS, the time between the date of initial diagnosis and death or last contact; DFS, the time between the date of surgery and identification of disease recurrence; CI, confidence interval; HR: hazard ratio.