Table 1.
Pharmacokinetics of frondoside A following bolus injection of 100 µg/kg in 0.7% DMSO in saline, either intraperitoneally or intravenously, in 10 male CD2F1 mice.
| Parameter | IP Bolus | IV Bolus |
|---|---|---|
| Area under curve (AUC) µg/L × min | 9984 | 47,220 |
| Total body clearance (Cltb) mL/min/m2 | 127 | 6.35 |
| Maximum plasma concentration (Cpmax) nM | 18.3 | 129 |
| Bioavailability (%) | 20 | 100 |
| Apparent volume of distribution (L/m2) | 28 | - |
| Volume of distribution (L/m2) | - | 0.87 |
| Half-life γ (T½ γ) minutes | 840 | 510 |
| Half-life α (T½ α: distribution phase) minutes | - | 2 |
| Half-life β (T½ β elimination phase) minutes | - | 158 |