Table 1. Metabolic data from the four groups after 4 weeks of dietary treatment.
| ApoE-/-ND | ApoE-/-HD | ApoE-/-/OPN-/-ND | ApoE-/-/OPN-/-HD | Significance (P value) |
|||
|---|---|---|---|---|---|---|---|
| n = 6 | n = 6 | n = 6 | n = 6 | Gene | Diet | Gene x Diet | |
| Body weight (g) | 25.17 ± 0.31 | 23.17 ± 0.17 | 25.67 ± 0.33 | 23.83 ± 0.31 | NS | < 0.05 | NS |
| Kidney weight (mg) | 183.33± 2.11 | 165 ± 3.41 | 183.33 ± 4.94 | 168.33 ± 4.77 | NS | < 0.05 | NS |
| TC (mg/dl) | 458 ± 39.47 | 2065± 138.42 | 362.5 ± 34.12 | 1640 ± 189.64 | < 0.05 | < 0.01 | NS |
| LDL-C (mg/dl) | 107.17 ± 12.1 | 519.17 ± 25.4 | 77.83 ± 5.32 | 414.17 ± 41.52 | < 0.05 | < 0.01 | NS |
| TG (mg/dl) | 119 ± 31.36 | 43.33 ± 9.89 | 92.5 ± 24.02 | 31.67 ± 3.07 | NS | < 0.05 | NS |
| BUN (mg/dl) | 27.8 ± 2.49 | 29.58 ± 1.65 | 23.35 ± 1.75 | 27.25 ± 1.5 | NS | NS | NS |
Abbreviations: TC, total cholesterol; LDL-C, low-density lipoprotein- cholesterol; TG, triglycerides; BUN, blood urea nitrogen. Data are analyzed by two-way ANOVA; n = 6 per group. NS, not significant.