Figure 6. Network disruption by BIRB-796.

(a) The method identified 17 communities with membership greater than 5 residues in DFG-out p38γ, of which only 10 are shown for clarity. Communities are represented in shades of color based on tertiary structure and regulatory element: N-lobe, yellow; C-lobe, purple; docking site, blue. Communities in the C-lobe (purple) are heavily overlapped and include the MAPK insert, portions of the GHI subdomain, and F-helix. Darker shades of purple indicate communities that include the F-helix, lighter shades of purple indicate communities that include the H-helix. (b) Communities are mapped on the DFG-out p38γ homology model, illustrating the disruption in communication between N and C-lobes. The docking site has become insular, represented by weak flow to other communities and membership only in the C-lobe.