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. 2016 Jun 29;6:28653. doi: 10.1038/srep28653

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Copyright © 2016, Macmillan Publishers Limited

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(A) Effects of TβRI/TβRII dual inhibitor LY2109761 and TβRI inhibitor SB431542 on GDF-15-induced up-regulation of mEPSC frequency. (B) Representative western blot and bar graph showing effect of GDF-15 on phosphorylated ERK1/ERK2 levels in the absence and presence of LY2109761 and SB431542. pERK1 and pERK2 levels were normalized by total ERK1 and ERK2 levels. (C) Representative recordings and bar graph showing the effect of GDF-15 on mEPSC frequencies in the absence and presence of MEK inhibitor U0126. Results are shown as means ± SEM. *p < 0.05 compared with corresponding control (without GDF-15) determined by unpaired Student’s t-test.