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. 2016 Jun 29;6:28653. doi: 10.1038/srep28653

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Copyright © 2016, Macmillan Publishers Limited

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(A) Representative recordings and bar graph showing effect of T-type VGCC blocker NiCl₂ on GDF-15-induced increase in mEPSC frequency. (B) Representative recordings and bar graph showing effect of T-type VGCC blocker mibefradil on GDF-15-induced increases in mEPSC frequency and glutamate release. (C) Representative recordings and bar graph showing the effects of T-type VGCC blocker TTA-P2 on the GDF-15-induced increase in mEPSC frequency and glutamate release. (D) Representative recordings and bar graph showing effect of L-type VGCC blocker nifedipine on GDF-15-induced increases in mEPSC frequency and glutamate release. Results are shown as means ± SEM. *p < 0.05 compared with corresponding control (without GDF-15) determined by unpaired Student’s t-test.