Table 4. Targeting of the glucose-6-phosphate dehydrogenase (G6PDH) and glutathione reductase (GR) in mature human erythrocytes by Bay 11–7082, parthenolide and dimethyl fumarate (DMF).
| Target | EC50 | EC100 | |
|---|---|---|---|
| Bay 11–7082 (20 μM) | G6PDH | 10 | 20 |
| Parthenolide (50 μM) | G6PDH | 12 | 50 |
| DMF (140 μM) | G6PDH | 140 | – |
| Bay 11–7082 (20 μM) | GR | 10 | 20 |
| DMF (140 μM) | GR | 140 | – |
The different percentages of inhibition of the G6PDH and GR activities achieved by each inhibitor are indicated as EC50 and/or EC100 values.