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. 2016 Jun 9;8(6):163. doi: 10.3390/v8060163

Figure 1.

Figure 1

Generalized structure of a minimal hammerhead ribozyme (hRz) and organization of the chikungunya virus (CHIKV) viral genome showing hRz target sites. (A) hRzs consist of helix I and III which mediate complementary base-pairing with the target, and helix II which acts as the catalytic core mediating cleavage of the target RNA; (B) Schematic of the CHIKV genome. nsP1–nsP4 = polyprotein encoded by the genomic RNA. Capsid, E3, E2, 6K and E1 = polyprotein encoded by the sub-genomic RNA. 9–15 = target sites for hRz#9-#15.