Table 2.
IFN-related host pathways targeted by diptera-borne phleboviruses.
| Phlebovirus | Host Target | Mechanism | References |
|---|---|---|---|
| RVFV | TFIIH p44, XPB | sequestration | [119] |
| TFIIH p62 | proteasomal degradation by recruitment of a SKP1-FBXO3 E3-ubiquitin ligase complex | [120,123,124] | |
| SAP30 | recruitment of suppressors to the IFN promoter | [126] | |
| mRNA export | unknown | [125] | |
| PKR | proteasomal degradation by recruitment of a SKP1-CUL1-FBXW11 E3 ligase complex | [93,111,127,128] | |
| TOSV | RIG-I | proteasomal degradation | [134,135,136] |
| PKR | proteasomal degradation | [132] | |
| PTV | IFN induction | unknown | [131] |
| SFSV | IFN induction | unknown | [93,131] |
PTV: Punta Toro virus; TFIIH: transcription factor II H; XPB: xeroderma pigmentosum type B; SAP30: Sin3A associated protein 30; RIG-I: retinoic acid-inducible gene 1.