Table 2.
Phlebovirus | Host Target | Mechanism | References |
---|---|---|---|
RVFV | TFIIH p44, XPB | sequestration | [119] |
TFIIH p62 | proteasomal degradation by recruitment of a SKP1-FBXO3 E3-ubiquitin ligase complex | [120,123,124] | |
SAP30 | recruitment of suppressors to the IFN promoter | [126] | |
mRNA export | unknown | [125] | |
PKR | proteasomal degradation by recruitment of a SKP1-CUL1-FBXW11 E3 ligase complex | [93,111,127,128] | |
TOSV | RIG-I | proteasomal degradation | [134,135,136] |
PKR | proteasomal degradation | [132] | |
PTV | IFN induction | unknown | [131] |
SFSV | IFN induction | unknown | [93,131] |
PTV: Punta Toro virus; TFIIH: transcription factor II H; XPB: xeroderma pigmentosum type B; SAP30: Sin3A associated protein 30; RIG-I: retinoic acid-inducible gene 1.