Table 2.
Rituximab Desensitization Protocol Initially Attempted in Patient 2
| Solution | Total volume (mL) | Drug per bag (mg) | Concentration (mg/mL) |
|---|---|---|---|
| 1 | 250 | 2.85 | 0.011 |
| 2 | 250 | 28.5 | 0.114 |
| 3 | 250 | 282.757 | 1.131 |
| Step | Solution | Rate (mL/h) | Rate (mg/kg/h) | Time (min) | Dose per step (mg) | Cumulative dose (mg) |
|---|---|---|---|---|---|---|
| 1 | 1 | 1.5 | 0.0008 | 20 | 0.0057 | 0.0057 |
| 2 | 1 | 3.75 | 0.002 | 20 | 0.0143 | 0.02 |
| 3 | 1 | 7.5 | 0.004 | 20 | 0.0285 | 0.0485 |
| 4 | 1 | 15 | 0.008 | 20 | 0.0570 | 0.1055 |
| 5 | 2 | 3.75 | 0.02 | 20 | 0.1425 | 0.248 |
| 6 | 2 | 7.5 | 0.05 | 20 | 0.285 | 0.533 |
| 7 | 2 | 15 | 0.1 | 20 | 0.57 | 1.103 |
| 8 | 2 | 30 | 0.2 | 20 | 1.14 | 2.243 |
| 9 | 3 | 7.5 | 0.5 | 20 | 2.8276 | 5.0705 |
| 10 | 3 | 15 | 0.9 | 20 | 5.6551 | 10.7257 |
| 11 | 3 | 22.5 | 1.4 | 20 | 8.4827 | 19.2084 |
| 12a | 3 | 30 | 1.8 | 20 | 11.3103 | 30.5187 |
| 13b | 3 | 40 | 2.4 | 20 | 15.0804 | 45.599 |
| 14 | 3 | 50 | 3 | 20 | 18.8505 | 64.4495 |
| 15 | 3 | 60 | 3.6 | 20 | 22.6206 | 87.0701 |
| 16c | 3 | 75 | 4.5 | 140 | 97.9299 | 285 |
Total infusion time: 440 min. Final infusion rate: 4.5 mg/kg/h.
a
Subsequent desensitizations.
b
Second desensitization to complete dose.
c
Initial desensitization.