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. 2016 Jun 29;6:28934. doi: 10.1038/srep28934

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Copyright © 2016, Macmillan Publishers Limited

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(a) Fura-2 assays of STC-1 cell monolayers demonstrated the concentration-dependent action of JWU-A021 to increase [Ca²⁺]_i. (b,c) A967079 and HC030031 each exerted concentration-dependent actions to counteract the stimulatory effect of JWU-A021 (1 μM) in STC-1 cells. (d) The TRPA1 channel activator AITC (10 μM) increased [Ca²⁺]_i, and this action of AITC was also reduced by A967079 and HC030031 in STC-1 cells. For these panels and subsequent figures, JWU-A021 was administered by bolus injection (Inj.). (e,f) Ca²⁺-elevating actions of JWU-A016 (e) and the A029-A034 series of test agents (f). For all examples depicted here, the findings are representative of a single experiment repeated a minimum of five times on five different occasions with similar results.