Figure 2.
Transport of synaptic vesicle precursors is disrupted in kif1bst43 mutants. A, B, Wild-type and kif1bst43 mutant kymographs representing synaptic vesicle precursor (labeled by Synaptophysin-mRFP) transport in pLL axons. Schematic of wild-type and kif1bst43 mutant kymographs illustrating anterograde (black) and retrograde (gray) traces. C, D, Anterograde distance and velocity of Synaptophysin transport is decreased in kif1bst43 mutants (ANOVA; sample size indicated on graphs). E, Number of Synaptophysin labeled vesicles moving in the anterograde and retrograde directions is decreased in kif1bst43 mutants (ANOVA). Error bars represent standard error of the mean.