TABLE 2.
Administrative Data: Diagnoses and Utilization During the 12 Months Prior to Newly Starting Antidepressant
| Characteristics | SSRI | Non-SSRI | |||||
|---|---|---|---|---|---|---|---|
| Citalopram | Fluoxetine | Paroxetine | Sertraline | Bupropion | Mirtazapine | Venlafaxine | |
| n = 78 | n = 76 | n = 73 | n = 64 | n = 86 | n = 98 | n = 81 | |
| Personality disorder (%) | 3.9 | 2.6 | 2.7 | 0.0 | 1.2 | 1.0 | 4.9 |
| Bipolar 2 (%) | 1.3 | 0 | 0 | 0 | 2.3 | 2.0 | 1.2 |
| Other anxiety disorder (%) | 16.7 | 15.8 | 24.7 | 17.2 | 15.1 | 18.4 | 13.6 |
| PTSD (%) | 14.1 | 10.5 | 12.3 | 9.4 | 10.5 | 21.4 | 19.8 |
| Service connected status (%) | 25.6 | 25.0 | 23.3 | 23.4 | 37.2 | 31.6 | 32.1 |
| Charlson index | 1 (1.4) | 0.8 (1.1) | 0.8 (1.3) | 1.0 (2.1) | 1.0 (1.8) | 1.0 (2.0) | 0.8 (1.5) |
| Alcohol abuse/dependence (%)a | 15.4 | 6.6 | 12.3 | 18.8 | 14.0 | 25.5 | 13.6 |
| Illicit drug abuse/dependence (%) | 7.7 | 6.6 | 9.6 | 17.2 | 7.0 | 15.3 | 12.4 |
| Tobacco use diagnosis (%)b | 15.4 | 10.5 | 15.1 | 17.2 | 37.2 | 12.2 | 16.1 |
| Suicide attempt (%)c | 1.3 | 0 | 0 | 0 | 0 | 0 | 1.2 |
| Number of | |||||||
| Psychiatric hospitalizationsa | 0.1 (0.3) | 0.01 (0.1) | 0.1 (0.4) | 0.2 (0.4) | 0.1 (0.3) | 0.3 (0.7) | 0.1 (0.5) |
| Nonpsychiatric hospitalizations | 0.2 (0.7) | 0.1 (0.4) | 0.2 (0.6) | 0.2 (0.6) | 0.2 (0.8) | 0.3 (0.9) | 0.3 (0.9) |
| Mental health outpatient visits | 6.0 (23.4) | 1.3 (2.1) | 3.2 (12.9) | 2.3 (4.7) | 4.4 (18.2) | 4.4 (9.1) | 4.8 (20.5) |
| Nonmental health outpatient visits | 10.2 (14.4) | 6.7 (7.2) | 8.5 (10.9) | 9.4 (11.2) | 11.1 (13.1) | 11.3 (14.4) | 9.7 (15.4) |
| Psychotropic medicationsb | 1.5 (0.8) | 1.4 (0.8) | 1.5 (0.7) | 1.3 (0.6) | 1.5 (0.9) | 1.8 (1.0) | 1.7 (1.0) |
Note: Cell values are mean (SD), unless otherwise stated.
a P < 0.05.
b P < 0.01 for comparison across all antidepressant agents by chi-square tests for categorical variables or analysis of variance for count variables.
c Based on ICD-9-CM E codes.
ICD-9-CM = International Classification of Diseases, Ninth Revision, Clinical Modification; PTSD = post-traumatic stress disorder; SD = standard deviation; SSRI = selective serotonin reuptake inhibitor.