(A) Mean values of dynamics of end-organ perfusion markers (arterial lactate, eGFR, and DO2) and liver function tests (Total bilirubin and INR) between patients in the GDT and Standard Arms. (B) Comparison of the hemodynamic parameters during the intraoperative resuscitation phase and PACU for patients in the standard vs goal-directed arm (GDT). CI, Cardiac index; SVI, stroke volume index; SVV, stroke volume variation. INR, international normalized ratio; eGFR, estimated glomerular filtration rate using modified in renal diet (MDRD) formula; DO2, oxygen delivery; GDT, goal-directed therapy arm; Preop, preoperative value; POD, postoperative day; PACU, post-anesthetic care unit; Resus, resusciation. P, two-way ANOVA between randomization arms.