Table 3.

Responses to PGT scenarios (n = 1,030)

Scenario 1: Alzheimer’s disease risk
(1) Based on these results, what are Lindsay’s chances of developing Alzhiemer’s disease compared to the average woman of her age and ethnicity? [correct answer = much higher]	66.0
(2) Based on her results, which of the following statements best describes Lindsay〉s chances of developing Alzheimer’s disease? [correct answer = she has a 43% chance of developing Alzheimer’s disease by age 79 (23andMe); she has a >13% chance of developing Alzheimer’s disease (Pathway)]	83.2
Scenario 2: Type 2 diabetes risk
(3) Based on his GENETIC results, what are Dan’s chances of developing diabetes compared to the average man of his age and ethnicity? [correct answer = somewhat lower]	59.2
(4) Based on his GENETIC results, will Dan develop diabetes? [correct answer = probably not]	82.3
(5) Which of the following is a true statement about Dan’s risk of diabetes? [correct answer = Dan’s obesity is an important risk factor for diabetes regardless of his genetic results]	93.1
Scenario 3: Carrier screening results
(6) Erin does not carry any variants/mutations for the diseases listed in the report. [correct answer = false]	96.8
(7) Erin herself likely has one of the diseases or conditions listed in the report. [correct answer = false]	81.1
(8) Erin’s children could inherit a variant or mutation for one of the conditions listed in the report. [correct answer = true]	97.4
Phenylketonuria (PKU) resultsa
(9a) Based on these results, what are the chances that Erin has phenylketonuria (PKU)? [correct answer = most likely does not have PKU]	71.0
(10a) The father of Erin’s child is a carrier of a PKU mutation. Based on these results, what is the chance for Erin’s child to have PKU? [correct answer = 25%]	63.6
Cystic fibrosis (CF) resultsa
(9b) Based on these results, what are the chances that Erin has cystic fibrosis (CF)? [correct answer = most likely does not have CF]	67.2
(10b) Based on these results, what is the chance that Erin is a carrier of a CF mutation? [correct answer = most likely is not a carrier]	74.8
Scenario 4: Statin drug response
(11) Based on his statin drug response results, what are Frank’s chances of myopathy while taking statin therapy? [correct answer = higher than average]	92.7
Average of correct responses across items	79.1

The results are presented as % correct.

^aParticipants were randomized to receive PKU or CF results.