(A) Plasma glucose and (B) Glycated Haemoglobin were measured in plasma and whole blood respectively collected from all mice at the completion of the study. C) Mean systolic blood pressure by tail cuff plethysmography. Data presented as Mean ± SD (n=10/group). WT – Wild Type, WT D – Wild Type Diabetic, RAGE KO – RAGE Knockout, AT-2 KO – Angiotensin II type 2 receptor Knockout. * p <0.05 vs WT, † p <0.05 vs RAGE KO, ‡ p <0.05 vs AT-2 KO, § p <0.05 vs RAGE KOD, ¶ p <0.05 vs WTD.