(A–B) Twenty four hour albumin excretion rates (AER) and (C–D) creatinine clearances were quantitated on plasma and urine samples collected from all mice with and without diabetes at study completion. AER and creatinine clearance were quantitated using ELISA and HPLC respectively. Since AER data was not normally distributed it is expressed as geometric mean ± tolerance factors. Values expressed as mean ± SD (n=10/group). WT – Wild Type, WT D – Wild Type Diabetic, RAGE KO – RAGE Knockout, AT-2R KO – Angiotensin II type 2 receptor Knockout.* p <0.05 vs WT, † p<0.05 vs AT-2 KO, ‡ p<0.05 vs WT D, § p < 0.05 vs RAGE KO D