At completion of the study renal tissue was collected to measure (A) RAGE gene expression by RT-PCR, (B) Renal membranous RAGE protein expression by ELISA, and (C) cytosolic and (D) mitochondrial superoxide production by lucigenin substrate enhanced chemiluminescence. Data presented as mean ± SD (n=10/group). WT – Wild Type, WT D – Wild Type Diabetic, RAGE KO – RAGE Knockout, AT-2R KO – Angiotensin II type 2 receptor Knockout.
* p<0.05 vs WT, † p<0.05 vs WT D, ‡ p<0.05 vs AT-2 KO, § p<0.05 vs RAGE KO D, ¶ p <0.05 vs RAGE KO