Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The different pathways altered by overexpression of GH. Cellular crosstalk between the epithelial and stromal compartments is mediated by growth factors, including IGF1, EGF, and FGFs, which bind to their receptors to induce cell proliferation and branching. The WNT5A pathway can also influence epithelial cells proliferation. High tension from cell-generated mechanical stress can promote the binding of growth factors to their receptors.
