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. 2016 May 25;17(6):817. doi: 10.3390/ijms17060817

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic model of citrate carrier (CiC) and carnitine-acylcarnitine translocase (CACT) in lipogenesis and β-oxidation, and their metabolic interrelationship. Abbreviations: ACC, acetyl-CoA carboxylase; CoA-SH, coenzyme-A; CPT1, carnitine palmitoyltransferase 1; CPT2, carnitine palmitoyltransferase 2; DNL, de novo lipogenesis; FAS, fatty acid synthase; IMM, inner mitochondrial membrane; IMS, intermembrane space; OAA, oxaloacetate; OMM, outer mitochondrial membrane; PFK-1, phosphofructokinase-1. The green arrow and dashed red lines represent, respectively, positive (+) and negative (-) allosteric modulation of the indicated target enzymes.