Table 2.

Targets of miR-21 associated with immunity and autoimmunity.

Name	Description	Cell Types	Function	Refs.
PDCD4	Programmed cell death 4	T cell	Inhibits T cell apoptosis	[14]
			Promotes T cell activation	[25]
		Macrophage	Promotes IL-10 production	[4]
SPRY1	Sprouty homolog 1	T cell	Promotes T cell activation	[5]
IL-12p35	Interleukin 12, subunit p35	DC	Inhibits Th1 differentiation	[17]
SMAD-7	Sma and Mad (Mothers against decapentaplegic) 7	T cell	Promotes Th17 differentiation	[18]
TIPE2	TNF-α-induced protein 8 (TNFAIP8)-like 2	T cell	Inhibits T cell apoptosis	[7]
PTEN	Phosphatase and tensin homolog	MDSC	Promotes MDSC expansion	[23]
RASGRP1	RAS guanyl-releasing protein 1	T cell	Promotes hypomethylation	[19]
CCR7	Chemokine C receptor 7	DC	Inhibits DC maturation	[22]
		T cell	Reduces T cell homing	[20]
JAG1	Jagged 1	DC	Promotes DC differentiation	[21]
TIMP3	Tissue inhibitor of metalloproteinase 3	Epidermal keratinocytes	Promotes inflammation	[24]
PLEKHA1	Pleckstrin homology domain-containing family A member 1	T cell	Inhibits T cell activation	[16]
GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha	T cell	Inhibits T cell activation	[16]
CXCR4	C-X-C chemokine receptor type 4	T cell	Inhibits T cell activation	[16]
FASL	Fas ligand	MCF-7	Inhibits T cell apoptosis	[15]

Abbreviations: MDSC, Myeloid-Derived Suppressor Cell; DC, Dendritic Cell; MCF-7, Breast cancer cell line.