Table 3.
miR-21 as a diagnostic biomarker for patients with autoimmune disease.
| Disease | Cells or Tissue | Expression | Refs. |
|---|---|---|---|
| SLE | plasma, PBMC, CD4+ cells | up-regulation | [25,26,27] |
| RA | plasma, memory CD4+ cells | up-regulation | [26,29] |
| RA | PBMC, CD4+ cells | down-regulation | [28] |
| MS | PBMC, brain lesions, CD4+ cells | up-regulation | [30,37] |
| Psoriasis | skin lesions | up-regulation | [18,31] |
| T1D | PBMC | up-regulation | [32] |
| UC | serum, mucosa, colon, saliva | up-regulation | [33,34] |
| UC, CD | blood | down-regulation | [34] |
| Asthma | bronchial epidermal cells | up-regulation | [35] |
| AIH-1 | serum | up-regulation | [36] |
Abbreviations: SLE, Systemic Lupus Erythematosus; RA, Rheumatoid Arthritis; MS, Multiple Sclerosis; T1D, type 1 diabetes; UC, ulcerative colitis; CD, Crohn’s disease; AIH-1, type-1 autoimmune hepatitis; PBMC, peripheral mononuclear cells.