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Role of MMPs in BCC tumor invasion. MMP-2 and MMP-13 secreted by fibroblasts facilitate tumor invasion. Inflammatory cells-derived MMP-9 degrades the basement membrane and promotes tumor invasion. BCC cells secrete MMP-7 and MMP-14. MMP-7 degrades the basement membrane, HB-EGF and E-cadherin, whereas, MMP-14 degrades the basement membrane, CD-44 and E-cadherin. Together, they play an important role in tumor invasion.
