Table 4.
The levels of metabolites, which showed significant differences between oral squamous cell carcinoma (OSCC) and normal tissues [59].
| Metabolites | Concentration (nmol/mg Wet Weight of Tissue) | ||
|---|---|---|---|
| Cancer | Normal | ||
| Glucose | 0.84 ± 0.67 #,* | 1.59 ± 1.31 | |
| EMP Pathway | |||
| 3PG | 0.38 ± 0.49 * | 1.64 ± 3.81 | |
| 2PG | 0.06 ± 0.07 * | 0.24 ± 0.54 | |
| Lactate | 76.7 ± 67.1 * | 51.9 ± 43.8 | |
| TCA cycle | |||
| Fum | 0.67 ± 0.36 * | 0.52 ± 0.33 | |
| Mal | 1.83 ± 1.36 * | 1.32 ± 0.88 | |
| The amino acids and the metabolites related to amino acids metabolism | |||
| Glutamine | 9.35 ± 7.53 $ | 11.0 ± 6.63 | |
| Glutamate | 13.8 ± 10.1 * | 9.92 ± 9.52 | |
| Glycine | 8.37 ± 7.94 * | 6.05 ± 6.17 | |
| Aspartate | 5.00 ± 4.69 * | 2.93 ± 3.54 | |
| Proline | 2.92 ± 3.29 * | 2.11 ± 2.35 | |
| Cysteine | 0.21 ± 0.21 * | 0.12 ± 0.14 | |
| Hydroxyproline | 0.34 ± 0.79 * | 0.23 ± 0.49 | |
| Creatine | 8.48 ± 9.39 * | 14.0 ± 12.9 | |
| Creatinine | 0.30 ± 0.47 * | 0.30 ± 0.27 | |
| Putrescine | 0.27 ± 1.07 * | 0.08 ± 0.29 | |
# Mean standard deviation; * Significant difference from the amount in normal tissue (p < 0.0125); $ The level of glutamine in OSCC was lower than that in normal tissues, although the difference was not significant. See Figure 1 for abbreviations of metabolites.