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Effects of SB203580 on the TBI-induced increase in ROS in HPCs and HSCs. Mice were treated with vehicle or SB203580 70 days after exposure to 6 Gy TBI, as described in the experimental section. BMNCs were collected from the mice 80 days after 6 Gy TBI, and the levels of intracellular ROS in the HSCs and HPCs were measured. The data are presented as the means ± SD. n = 12 mice/group; a p < 0.05 vs. control; b p < 0.05 vs. TBI + vehicle.
