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. 2016 Jun 9;17(6):910. doi: 10.3390/ijms17060910

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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CLC-2 knockdown attenuates transforming growth factor (TGF)-β1-induced collagen I and fibronectin expression. Human conjunctival fibroblasts (HConF) treated with TGF-β1 had elevated levels of collagen I and fibronectin expression compared to untreated control cells. Cells transfected with CLC-2 siRNA in the presence of TGF-β1 showed decreased mRNA and protein expression of collagen I and fibronectin compared to nontransfected and mutant CLC-2 siRNA transfected cells, whereas nontransfected and mutant siRNA transfected cells had similar collagen I and fibronectin expression levels; Data are presented as the mean ± SD (n = 4); FN: fibronectin; siRNA-NC: mutant CLC-2 siRNA; * p < 0.05, ** p < 0.01 vs. control; # p < 0.05, ## p < 0.01 vs. TGF-β1 in ANOVA.