Table 4.
Down-regulated circulating miRNAs for GC.
| Circulating Tumor Suppressor miRs | Samples | Methods | Sensitivity | Specificity | AUC | Target (Official Gene Name) | Clinical Application | References |
|---|---|---|---|---|---|---|---|---|
| miR-122 | 12 GC 12 HC |
qRT-PCR | ND | ND | 0.808 | ND | Distance metastases Poor Survival Prognosis No Distant metastasis Diagnosis |
[189] |
| miR-195-5p | 20 GC 190 HC |
qRT-PCR | ND | ND | ND | ND | Prognosis | [209,210] |
| miR-203 | 154 GC 22 HC |
qRT-PCR | ND | ND | ND | ND | Gender Lymphatic invasion Venous invasion Peritoneal metastasis Distance metastasis LNM Liver metastasis TNM stage Poor Survival Prognosis |
[211] |
| miR-218 | 68 GC 56 HC |
qRT-PCR | ND | ND | ND | ECOP | Metastasis Tumor stage Poor Survival Prognosis |
[155,198] |
| miR-375 | NA | Microarray + qRT-PCR | 0.85 | 0.80 | 0.835 | ND | Prognosis | [210] |
GC: Gastric cancer; HC: Healthy control; Pre: pre-operative; Post: post-operative; qRT-PCR: Quantitative reverse transcriptase polymerase chain reaction; AUC: Area under curve; ND: not determined.